Cancer Genomics
Oncogenomics also called Cancer genomics is one
among the sub-field of genomics that characterizes cancer-associated genes.
Cancer is a hereditary disease caused by accumulation of DNA mutations and
epigenetic changes leading to unrestricted cell proliferation and neoplasm
formation. It emphases on genomic, epigenomic and transcript alterations in
cancer. The cancer genomics has a goal to identify new oncogenes or tumor
suppressor genes that may offer new insights into cancer diagnosis, predicting
clinical outcome of cancers and new targets for cancer therapies. The success
of targeted cancer therapies such as Gleevec, Herceptin and Avastin elevated
the hope for oncogenomics to elucidate new targets for cancer treatment.
All the DNA enclosed in your cells makes up your genome.
In most cells, the genome is embalmed into two sets of chromosomes: one set
from your mother and one set from your father. These chromosomes are collected
of six billion individual DNA letters. DNA of our genes there are four letters:
A, C, G and T. Genomics is the study of the sequence of these letters in your
DNA and how each rope of letters passes information to help each cell in your
body work properly.
In cancer cells, small deviations in the genetic
letters can change what a genomic word or sentence means. A altered letter can
cause the cell to make a protein that doesn’t allow the cell to work as it
should. These proteins can make cells grow quickly and cause damage to next
cells. Upcoming the cancer genome,
scientists can discover what letter changes are causing a cell to become a
cancer. The genome of a cancer cell can also be used to tell one type of cancer
from a new. In cases, cramming the
genome in a cancer can help detect a subtype of cancer within that type, such
as HER2+ breast cancer.
Cancer is no extensive seen as just one disease, but
a collection of hundreds of diseases, each with unique individualities and its
own genetic make-up. For model, lung cancer was once alleged of as a single virus,
but we now know it can be categorised into at least 12 discrete subtypes based
on the molecular alterations mutations that drive its growth.
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